Pulmonary Abnormalities in Young, Light-Use Water Pipe (Hookah) Smokers.

Publication TypeJournal Article
Year of Publication2016
AuthorsStrulovici-Barel Y, Shaykhiev R, Salit J, Deeb RS, Krause A, Kaner RJ, Vincent TL, Agosto-Perez F, Wang G, Hollmann C, Shanmugam V, Almulla AM, Sattar H, Mahmoud M, Mezey JG, Gross SS, Staudt MR, Walters MS, Crystal RG
JournalAm J Respir Crit Care Med
Date Published2016 Sep 01
KeywordsAdult, Carbon Monoxide, Carboxyhemoglobin, Case-Control Studies, Cell-Derived Microparticles, Cotinine, Cough, Epithelial Cells, Female, Forced Expiratory Volume, Humans, Lung, Male, Nicotine, Pulmonary Alveoli, Pulmonary Diffusing Capacity, Smoking, Sputum, Thorax, Tobacco Use Disorder, Tomography, X-Ray Computed, Transcriptome, Young Adult

RATIONALE: Water pipes, also called hookahs, are currently used by millions of people worldwide. Despite the increasing use of water pipe smoking, there is limited data on the health effects of water pipe smoking and there are no federal regulations regarding its use.

OBJECTIVES: To assess the effects of water pipe smoking on the human lung using clinical and biological parameters in young, light-use water pipe smokers.

METHODS: We assessed young, light-use, water-pipe-only smokers in comparison with lifelong nonsmokers using clinical parameters of cough and sputum scores, lung function, and chest high-resolution computed tomography as well as biological parameters of lung epithelial lining fluid metabolome, small airway epithelial (SAE) cell differential and transcriptome, alveolar macrophage transcriptome, and plasma apoptotic endothelial cell microparticles.

MEASUREMENTS AND MAIN RESULTS: Compared with nonsmokers, water pipe smokers had more cough and sputum as well as a lower lung diffusing capacity, abnormal epithelial lining fluid metabolome profile, increased proportions of SAE secretory and intermediate cells, reduced proportions of SAE ciliated and basal cells, markedly abnormal SAE and alveolar macrophage transcriptomes, and elevated levels of apoptotic endothelial cell microparticles.

CONCLUSIONS: Young, light-use, water-pipe-only smokers have a variety of abnormalities in multiple lung-related biological and clinical parameters, suggesting that even limited water pipe use has broad consequences on human lung biology and health. We suggest that large epidemiological studies should be initiated to investigate the harmful effects of water pipe smoking.

Alternate JournalAm. J. Respir. Crit. Care Med.
PubMed ID27007171
PubMed Central IDPMC5027211
Grant ListP20 HL113443 / HL / NHLBI NIH HHS / United States
R01 HL107882 / HL / NHLBI NIH HHS / United States
UL1 RR024143 / RR / NCRR NIH HHS / United States
UL1 TR000457 / TR / NCATS NIH HHS / United States