1035 York Avenue Building

Ronald G. Crystal, M.D.
Chairman, Genetic Medicine

Genetic Therapies and Personalized Medicine

Our translational research program includes many projects in the fields of genetic therapies and personalized medicine. The field of genetic therapies comprises gene and stem cell therapies and our laboratory has extensive expertise in both areas. Our group was the first to use a recombinant virus as a vehicle for in vivo gene therapy and we have carried out human trials of gene therapy for cystic fibrosis, cardiac ischemia, cancer and central nervous system disorders. Among the current projects are gene transfer strategies for cancer, inherited CNS disorders, α1-antitrypsin deficiency, anti-bioterrorism applications and development of vaccines. We also operate the clinical vector production laboratory of the Belfer Gene Therapy Core Facility, which has produced adenovirus and adeno-associated virus vectors that have been used in numerous human studies. Current projects in the field of stem cell therapy include characterization of the roles of cancer stem cells in lung cancer and the role of airway epithelium stem cells in chronic obstructive pulmonary disease.

Personalized medicine is the use of information and data from an individual's genotype, or level of gene expression to stratify complex diseases, select a medication or dose of a medication, provide a therapy, or initiate a preventative measure that is specifically suited to that patient. In addition to genetic information, other factors, including imaging, laboratory, and clinical information about the disease process or the patient are integrated into the process of developing personalized medicine. Our group utilizes microarray technologies for genome-wide characterization of gene expression, single nucleotide polymorphism and copy number variation profiles on clinical samples as the basis for projects aimed at indentifying candidate genes associated with complex disease such as chronic obstructive pulmonary disease.

The overall research program of the group includes close collaborations with other laboratories at Weill Cornell and elsewhere, including Malcolm Moore's group at Memorial Sloan Kettering Cancer Center for stem cell projects. Of particular note are our collaborations on personalized medicine projects with colleagues at Weill Cornell Medical College-Qatar and Hamad Medical Corporation in Doha, Qatar and collaborations on Bioinformatics and Biostatistical Genetics with several laboratories at Cornell-Ithaca, including Andy Clark and Jason Mezey.


Full and Part Time Faculty


  • Ballon, Douglas J.
    Associate Professor of Physics in Radiology.
    Associate Professor of Genetic Medicine.
    Adjunct Associate Professor of Physics in Radiology, Columbia University College of Physicians and Surgeons.

    B.S. 1980, Rutgers-The State University of New Jersey; Ph.D. 1985, Rutgers-The State University of New Jersey.
    Research Profile
  • Butler, Jason Mathew
    Assistant Professor of Genetic Medicine.
    Assistant Professor of Genetic Medicine in Surgery

    Ph.D. 2005, University of Florida.
    Research Profile
  • Chiuchiolo, Maria Jose
    Assistant Research Professor of Genetic Medicine.
    M.S. 1992, National University of Teguman (Argentina); Ph.D. 2001, National University of Teguman (Argentina).
    Research Profile
  • Choi, Augustine M.K.
    Sanford I. Weill Chairman of Medicine.
    Professor of Genetic Medicine.
    Physician-in-Chief, NewYork-Presbyterian Hospital.

    B.S. 1980, University of Kentucky; M.D. 1984, University of Louisville School of Medicine; A.M. 2007, Harvard University.
    Research Profile
  • Chung, Pui Yee
    Instructor in Genetic Medicine.
    B.Sc. 1998, University of Hong Kong (China); M.Phil. 2000, University of Hong Kong (China); Ph.D. 2004, University of Hong Kong (China).
    Research Profile
  • Crystal, Ronald G.
    The Bruce Webster Professor of Internal Medicine.
    Professor of Medicine.
    Professor of Genetic Medicine.

    B.A. 1962, Tufts University; M.S. 1963, University of Pennsylvania; M.D. 1968, University of Pennsylvania School of Medicine.
    Clinical Profile
    Research Profile
  • Ding, Bi-Sen
    Assistant Professor of Genetic Medicine.
    B.S. 2000, Nanjing University (China); M.S. 2003, Nanjing University (China); Ph.D. 2008, University of Pennsylvania.
    Research Profile
  • Harvey, Ben-Gary
    Associate Professor of Clinical Medicine.
    Associate Professor of Genetic Medicine.
    Associate Attending Physician,
    NewYork-Presbyterian Hospital.
    B.A. 1978, American College (Colombia); M.D. 1985, University of the North Division of Health Sciences (Colombia).
    Clinical Profile
    Research Profile
  • James, Daylonv Assistant Professor of Stem Cell Biology in Obstetrics and Gynecology.
    Assistant Professor of Stem Cell Biology in Reproductive Medicine.
    Assistant Professor of Genetic Medicine..

    B.S. 1999, Duke University; Ph.D. 2006, The Rockefeller University.
    Research Profile
  • Kaminsky, Stephen M.
    Associate Research Professor of Genetic Medicine.
    B.S. 1979, Cornell University; M.Phil. 1983, Yale University; Ph.D. 1988, Yale University.
    Research Profile
  • Kaner, Robert Jeffrey
    James P. Smith, M.D. Clinical Scholar.
    Associate Professor of Clinical Medicine.
    Associate Professor of Genetic Medicine.

    B.A. 1978, Brandeis University; M.D. 1982, University of Pennsylvania School of Medicine.
    Clinical Profile
    Research Profile
  • Krieger, Ana C.
    Associate Professor of Clinical Medicine.
    Associate Professor of Medicine in Clinical Neurology.
    Associate Professor of Clinical Genetic Medicine.

    M.D. 1993, Federal University, Rio Grande Sul, Faculty of Medicine (Brazil); M.P.H. 2008, New York University.
    Clinical Profile
    Research Profile
  • Lipkin, Steven M.
    Associate Professor of Medicine.
    Associate Professor of Genetic Medicine.
    Associate Attending Physician, NewYork-Presbyterian Hospital.

    B.A. 1986, Princeton University; M.D., Ph.D. 1995, University of California, San Diego School of Medicine.
    Clinical Profile
    Research Profile
  • Martinez, Fernando J.
    Gladys and Roland Harriman Professor of Medicine.
    Professor of Genetic Medicine.
    Attending Physician, NewYork-Presbyterian Hospital.

    B.S. 1980, University of Florida; M.D. 1983, University of Florida
    College of Medicine; M.S. 2001, University of Michigan
    School of Public Health.

    Research Profile
  • Mezey, Jason
    Associate Professor of Genetic Medicine.
    Associate Professor of Computational Biomedicine.

    B.A. 1994, University of Pennsylvania; Ph.D. 2000, Yale University.Research Profile
  • Pagovich, Odelya Edith
    Instructor in Genetic Medicine.
    Instructor in Medicine.
    Assistant Attending Physician, NewYork-Presbyterian Hospital.

    B.A. 2001, Boston University; M.D. 2007, Sackler School of Medicine, Tel Aviv University (Israel).
    Research Profile
  • Rodriguez-Flores, Juan Lorenzo
    Instructor in Genetic Medicine.
    B.S. 1998, Massachusetts Institute of Technology; M.S. 2006, University of California, San Diego; Ph.D. 2009, University of California, San Diego.
    Research Profile
  • Shaykhiev, Renat
    Assistant Professor of Genetic Medicine.
    M.D. 2000, Kazan State Medical University (Russia); Ph.D. 2007, Philipps University, Marburg (Germany).
    Research Profile
  • Sondhi, Dolan
    Associate Research Professor of Genetic Medicine.
    B.S. 1991, St. Stephens College, Delhi University (India); Ph.D. 1997, Brown University.
    Research Profile
  • Staudt, Michelle R.
    Assistant Research Professor of Genetic Medicine.
    B.S. 2001, University of Oklahoma; Ph.D. 2006, University of Oklahoma Health Science Center.
    Research Profile
  • Walters, Matthew Stuart Assistant Research Professor of Genetic Medicine. B.Sc. 2000, University of Liverpool (United Kingdom); Ph.D. 2004, University of Leeds School of Medicine (United Kingdom).Research Profile
  • Wang, Baolin
    Associate Professor of Genetic Medicine.
    Associate Professor of Cell and Developmental Biology.

    B.S. 1982, Shanghai Normal University (China); M.S. 1985, Fudan University (China); Ph.D. 1996, University of Pennsylvania.
    Research Profile
  • Wang, Guoqing
    Instructor in Genetic Medicine. B.M. 2003, West China University of Medical Sciences (China);
    Ph.D. 2006, Sichuan University (China).

    Research Profile
  • Worgall, Stefan
    Distinguished Professor of Pediatric Pulmonology.
    Professor of Pediatrics.
    Professor of Genetic Medicine.

    M.D. 1991, University of Heidelberg, Faculty of Medicine (Germany); Ph.D. 1992, University of Heidelberg (Germany).
    Clinical Profile
    Research Profile
  • Zhang, Haijun
    Instructor in Genetic Medicine.
    B.M. 2003, Weifang Medical College (China); Ph.D. 2009, Peking University (China).
    Research Profile

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