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Clinical Trials

Research Studies

Cocaine Clinical Trial

Status: Currently recruiting volunteers

Safety Study of a Disrupted Adenovirus Serotype Cocaine Vaccine for Cocaine-dependent Individuals

The purpose of this clinical trial is to assess the safety and preliminary efficacy of a vaccine for individuals with cocaine dependence. The vaccine is designed to evoke an immune system response and prevent cocaine from reaching the brain. This trial is a phase 1, double-blind, placebo-controlled study. All inquiries are confidential.

Criteria: Adults with cocaine dependence

Study duration: 32 weeks

Age: 21 to 69 years old

Compensation: up to $2400

If you are interested in learning more about this study, please contact us at: 646-962-2672.


Cystic Fibrosis Research Study

Status: Currently recruiting volunteers

Collection of Airway, Blood and/or Urine Specimens from Subjects for Research Studies

The purpose of this study is to obtain biological specimens from individuals with Cystic Fibrosis (CF) in order to understand the pathogenesis and etiology of CF. Interested participants should be comfortable with undergoing a bronchoscopy procedure.

Criteria: Adults with Cystic Fibrosis

Study duration: 2 visits

Age: 18 and older

Compensation: up to $250

If you are interested in learning more about this study, please contact us at: 646-962-2672.


Gene Therapy for Alzheimer's Disease

Status: Currently recruiting volunteers

Gene Therapy for APOE4 Homozygote Alzheimer’s Disease

The purpose of this trial is to assess the safety and preliminary efficacy of a gene therapy for individuals who are ApoE4/E4 and diagnosed with mild cognitive impairment (MCI) and/or Alzheimer’s disease (AD). The gene therapy is composed of a viral vector coding for ApoE2. The E2 allele is the rarest form of ApoE and carrying even one copy appears to reduce the risk of developing Alzheimer’s by up ot 40%. The goal of the trial is to add the ApoE2 gene into the central nervous system to compensate for the effects of ApoE4, and thus prevent or delay the progression of AD. This trial is a phase 1, open-label, dose-ranging study.

Criteria:ApoE4 homozygotes diagnosed with mild cognitive impairment (MCI) and/or Alzheimer’s disease (AD)

Study duration: 1 year

Age:50 years old or older

Compensation:Please inquire

If you are interested in learning more about this study, please contact us at: 646-962-2672.


Friedreich's Ataxia Study

Status: Currently recruiting volunteers

Characterization of the Cardiac Phenotype of Friedreich’s Ataxia

The purpose of this study is to evaluate corneal confocal microscopy (CCM) as a tool for physicians and subjects to follow the onset, progression and ultimately, a potential therapy for Friedreich’s Ataxia (FA). CCM is a non-invasive examination of the number and structure of nerve cells in the cornea.

Criteria:Individuals diagnosed with Friedreich’s Ataxia (FA)

Study duration: 2 visits

Age: 12 to 30 years old

Compensation: Please inquire

If you are interested in learning more about this study, please contact us at: 646-962-2672.


Hookah Research Study

Status: Currently recruiting volunteers

Collection of Airway, Blood and/or Urine Specimens from Subjects for Research Studies

The purpose of this study is to obtain biological specimens from individuals who smoke hookah in order to understand the effects of hookah smoking on lung health. Interested participants should be comfortable with undergoing a bronchoscopy procedure.

Criteria: Adults who smoke hookah at least once a month

Study duration: 2 visits

Age: 18 to 50 years old

Compensation: up to $250

If you are interested in learning more about this study, please contact us at: 646-962-2672.


Idiopathic Pulmonary Fibrosis (IPF) Research Study

Status: Currently recruiting volunteers

Collection of Airway, Blood and/or Urine Specimens from Subjects for Research Studies

The purpose of this study is to obtain biological specimens from individuals with Idiopathic Pulmonary Fibrosis (IPF) in order to understand the pathogenesis and etiology of IPF. Interested participants should be comfortable with undergoing a bronchoscopy procedure.

Criteria: Adults with IPF

Study duration: 2 visits

Age: 18 years old and older

Compensation: up to $250

If you are interested in learning more about this study, please contact us at: 646-962-2672.


Rheumatoid Arthritis-associated Interstitial Lung Disease (RA-ILD) Research Study

Status: Currently recruiting volunteers

Collection of Airway, Blood and/or Urine Specimens from Subjects for Research Studies

The purpose of this study is to obtain biological specimens from individuals with Rheumatoid Arthritis-associate Interstitial Lung Disease (RA-ILD) in order to understand the pathogenesis and etiology of RA-ILD. Interested participants should be comfortable with undergoing a bronchoscopy procedure to collect samples from airways.

Criteria: Adults with RA-ILD

Study duration: 2 visits

Age: 18 years old and older

Compensation: up to $250

If you are interested in learning more about this study, please contact us at: 646-962-2672.


Scleroderma-associated Interstitial Lung Disease (Sc-ILD) Research Study

Status: Currently recruiting volunteers

Collection of Airway, Blood and/or Urine Specimens from Subjects for Research Studies

The purpose of this study is to obtain biological specimens from individuals with Scleroderma-associate Interstitial Lung Disease (Sc-ILD) in order to understand the pathogenesis and etiology of Sc-ILD. Interested participants should be comfortable with undergoing a bronchoscopy procedure to collect samples from airways.

Criteria: Adults with Sc-ILD

Study duration: 2 visits

Age: 18 years old and older

Compensation: up to $250

If you are interested in learning more about this study, please contact us at: 646-962-2672.


HIV Research Study

Status: Currently recruiting volunteers

Collection of Airway, Blood and/or Urine Specimens from Subjects for Research Studies

The purpose of this study is to obtain biological specimens from individuals who are positive for HIV in order to understand the interaction between HIV and lung health. Interested participants should be comfortable with undergoing a bronchoscopy procedure.

Criteria: Adults with HIV

Study duration: 2 visits

Age: 18 to 50 years old

Compensation: up to $250

If you are interested in learning more about this study, please contact us at: 646-962-2672.


Mucopolysaccharidosis Type IIIA (MPS IIIA) Research Study

Status: Currently recruiting volunteers

Study of AAVrh10-hSGSH Gene Therapy in Patients with Mucopolysaccharidosis Type IIIA (MPS IIIA)

LYS-SAF 302 is a gene therapy which is intended to deliver a functional copy of the SGSH gene to the brain. This is a phase 2/3 study to assess the efficacy in improving or stabilizing the neurodevelopmental state of MPS IIIA patients. The study is interventional, single arm and multi-center.

Criteria: Children diagnosed with MPS IIIA

Study duration: 5 years

Age: 6 months and older

Compensation: Eligible travel, accommodations and meal stipend

If you are interested in learning more about this study, please contact us at: 646-962-2672.

FAQs

General information for potential volunteers

What is a research study? What is a clinical trial?

A research study is a scientific way to improve or develop new methods of health care. Studies are designed to answer specific questions on how to treat, prevent, screen for, and diagnose different diseases and disorders. Many types of research studies exists. For example, clinical trials tests whether new medicines, therapies or devices are safe and effective. Other studies collect biological specimens, like blood, urine or airway samples, to understand health.

What is a placebo?

In clinical trials, drugs are often compared with placebos to check the effectiveness of that drug. A placebo is an inactive substance which may resemble an active substance but has no value to treat or prevent an illness. 

What is a bronchoscopy?

 This study procedure consists of the passage of a flexible tube through the mouth or nose into the airways. This will allow us to see into the large and small spaces inside the lungs and airways.  This procedure will allow us to get samples of airway cells by brushing, tissue sampling, lavage and/or washings

Should I volunteer?

There are many reasons for joining a research study. You may want to:

Learn about ways to possibly improve your health

Participate in a study that is trying to better understand a condition that you have

Gain access to novel treatments that are not otherwise available

Help others by contributing to medical knowledge

Will I be compensated?

Financial compensation is available for many of our research studies. Please reach out to us for additional information.

Who can participate?

Each study has its own rules about who can or cannot participate. This is called eligibility. Your eligibility may be based on your age, overall health, type and stage of a disease, smoking habit, and other condition. Things that allow you to participate are called inclusion criteria, and things that disqualify you are called exclusion criteria.

Are there risks or side effects to being in a research study?

Sometimes research procedures and drugs may cause discomfort and/or side effects. The study team will discuss with you known possible risks so you can decide if you want to volunteer. If you do participate in the study, you will be closely monitored for safety and any potential health-related concern will be discussed with you. In addition, the study team will inform you about any new risks that are learned during the duration of your study participation. Please reach out to us with any concerns or questions that you may have regarding study related risks.

What is informed consent? What is an informed consent form?

Informed consent is a process used by researchers to explain and describe potential risks and benefits of participation in a research study. This also includes an in depth discussion of study requirements and activities that would occur if a participant agreed to join the study. You will be provided with an informed consent form to read and review. Before you participate in a study, a member of the study team will review the form with you and answer any questions you may have. If you decide to join a study, you will be asked to sign the form.

What if I do not want to take part in a research study?

You can withdraw from the study at any time.

Who can I contact if I have additional questions?

You can call us at (646) 962 2672 or email us at cora@med.cornell.edu with any questions and a study coordinator will get back to you.

(646) 962 2672

Contact Information

Genetic Medicine 1305 York Ave., 13th Floor New York, NY 10065 Phone: (646) 962-2672 Fax: (646) 962-0380