Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population.

Publication Type	Academic Article
Authors	Upadhyay R, Robay A, Fakhro K, Abi Khalil C, Zirie M, Jayyousi A, El-Shafei M, Kiss S, D'Amico D, Salit J, Staudt M, O'Beirne S, Chen X, Tuana B, Crystal R, Ding H
Journal	J Transl Med
Volume	13
Pagination	61
Date Published	02/15/2015
ISSN	1479-5876
Keywords	Diabetes Mellitus, Type 2, Diabetic Retinopathy, Genetic Predisposition to Disease, Membrane Proteins, Polymorphism, Single Nucleotide
Abstract	BACKGROUND: Overexpression of SLMAP gene has been associated with diabetes and endothelial dysfunction of macro- and micro-blood vessels. In this study our primary objective is to explore the role of SLMAP gene polymorphisms in the susceptibility of type 2 diabetes (T2DM) with or without diabetic retinopathy (DR) in the Qatari population. METHODS: A total of 342 Qatari subjects (non-diabetic controls and T2DM patients with or without DR) were genotyped for SLMAP gene polymorphisms (rs17058639 C > T; rs1043045 C > T and rs1057719 A > G) using Taqman SNP genotyping assay. RESULTS: SLMAP rs17058639 C > T polymorphism was associated with the presence of DR among Qataris with T2DM. One-way ANOVA and multiple logistic regression analysis showed SLMAP SNP rs17058639 C > T as an independent risk factor for DR development. SLMAP rs17058639 C > T polymorphism also had a predictive role for the severity of DR. Haplotype Crs17058639Trs1043045Ars1057719 was associated with the increased risk for DR among Qataris with T2DM. CONCLUSIONS: The data suggests the potential role of SLMAP SNPs as a risk factor for the susceptibility of DR among T2DM patients in the Qatari population.
DOI	10.1186/s12967-015-0411-6
PubMed ID	25880194
PubMed Central ID	PMC4335364