Investigation of the role of the base in the synthesis of [18F]FLT.
| Publication Type | Academic Article |
| Authors | Suehiro M, Vallabhajosula S, Goldsmith S, Ballon D |
| Journal | Appl Radiat Isot |
| Volume | 65 |
| Issue | 12 |
| Pagination | 1350-8 |
| Date Published | 07/25/2007 |
| ISSN | 0969-8043 |
| Keywords | Dideoxynucleosides, Fluorine Radioisotopes, Radiopharmaceuticals |
| Abstract | The role of the base in the synthesis of 3'-deoxy-3'-[18F]fluorothymidine, [18F]FLT, via nucleophilic substitution of the nosyl group with [18F]fluoride was investigated. The rate of 18F-incorporation into the molecule dramatically changed as a function of the precursor-to-base ratio. In the presence of excess base, the precursor was consumed by elimination before substitution was complete. When the precursor-to-base ratio was optimal, an overall [18F]FLT yield of 30-40% was achieved even if the precursor amount was as small as 8-13 mg. |
| DOI | 10.1016/j.apradiso.2007.07.013 |
| PubMed ID | 17919915 |