Evaluation of fluorine-18-BPA-fructose for boron neutron capture treatment planning.

Publication Type	Case Report
Authors	Kabalka G, Smith G, Dyke J, Reid W, Longford C, Roberts T, Reddy N, Buonocore E, Hübner K
Journal	J Nucl Med
Volume	38
Issue	11
Pagination	1762-7
Date Published	11/01/1997
ISSN	0161-5505
Keywords	Boron Compounds, Boron Neutron Capture Therapy, Brain Neoplasms, Fluorine Radioisotopes, Fructose, Glioblastoma, Phenylalanine, Radiation-Sensitizing Agents, Tomography, Emission-Computed
Abstract	UNLABELLED: Boron neutron capture therapy (BNCT) using 4-[10B]boronophenylalanine-fructose (BPA-Fr) is in Phase II clinical trials to validate BNCT as a treatment for glioblastoma multiforme and melanoma. Successful BNCT depends on knowledge of the distribution of boron-containing agents in both tumor and normal tissue as currently determined by chemical confirmation of boron deposition in surgically removed malignant tissue before BNCT. METHODS: We used PET to noninvasively obtain in vivo information on the pharmacokinetics of the 18F-labeled analog of BPA-Fr in two patients with glioblastoma multiforme. Time-activity curves generated from the bolus injection of 18F-BPA-Fr were coinvolved to simulate a continuous infusion used for BNCT therapy. RESULTS: Distribution of 18F-BPA-Fr by PET was found to be consistent with tumor as identified by MR imaging. The 18F-BPA-Fr tumor-to-normal brain uptake ratio was 1.9 in Patient 1 and 3.1 in Patient 2 at 52 min after injection. The 18F-BPA-Fr uptake ratio in glioblastoma paralleled that of nonlabeled BPA-Fr seen in patients as previously determined by boron analysis of human glioblastoma tissue obtained from pre-BNCT surgical biopsy. CONCLUSION: Knowledge of the biodistribution of BPA-Fr enables pre-BNCT calculation of expected tissue dosimetry for a selected dose of BPA-Fr at a specific neutron exposure. Fluorine-18-BPA-Fr PET is capable of providing in vivo BPA-Fr biodistribution data that may prove valuable for patient selection and pre-BNCT treatment planning.
PubMed ID	9374349