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The Department of Genetic Medicine at Weill Cornell leads a dynamic and innovative translational research program, advancing diverse fields such as Genetic Therapy and Personalized Medicine.
Adenovirus-based genetic vaccines for biodefense.
| Publication Type | Review |
| Authors | Boyer J, Kobinger G, Wilson J, Crystal R |
| Journal | Hum Gene Ther |
| Volume | 16 |
| Issue | 2 |
| Pagination | 157-68 |
| Date Published | 02/01/2005 |
| ISSN | 1043-0342 |
| Keywords | AIDS Vaccines, Adenoviridae, Bioterrorism, Communicable Disease Control, Genetic Therapy, HIV Infections |
| Abstract | The robust host responses elicited against transgenes encoded by (E1-)(E3-) adenovirus (Ad) gene transfer vectors can be used to develop Ad-based vectors as platform technologies for vaccines against potential bioterror pathogens. This review focuses on pathogens of major concern as bioterror agents and why Ad vectors are ideal as anti-bioterror vaccine platforms, providing examples from our laboratories of using Ad vectors as vaccines against potential bioterror pathogens and how Ad vectors can be developed to enhance vaccine efficacy in the bioterror war. |
| DOI | 10.1089/hum.2005.16.157 |
| PubMed ID | 15761256 |