About Us
The Department of Genetic Medicine at Weill Cornell leads a dynamic and innovative translational research program, advancing diverse fields such as Genetic Therapy and Personalized Medicine.
Analysis of Genomic Variants in Populations
Areas Of Investigation
- Pharmacogenomics
- Precision medicine
- Relationship between genomic variation and response to therapeutic drugs
Research Questions
- Which genomic variants lead to differences in how a patient responds to medication, including gene therapy vectors?
- How do genomic variants differ among human populations?
Recent News
- DGM presents data on genomic variants with potential to affect AAV-mediated gene therapy at the 26th Annual Meeting of the American Society for Gene and Cell Therapy, Los Angeles, CA, May 6th to May 11th, 2023
- Qatar project highlights the importance of population-specific genetic screening tools for personalized medicine (January 2022)
Recent Publications
- Rostami, M. R., Leopold, P. L., Vasquez, J. M., de Mulder Rougvie, M., Al Shakaki, A., Hssain, A. A., Robay, A., Hackett, N. R., Mezey, J. G., & Crystal, R. G. (2023). Predicted deleterious variants in the human genome relevant to gene therapy with adeno-associated virus vectors. Molecular Therapy - Methods & Clinical Development, 31, 101136. doi: 10.1016/j.omtm.2023.101136.
- Rodriguez-Flores, J. L., Messai-Badji, R., Robay, A., Temanni, R., Syed, N., Markovic, M., Al-khayat, E., Qafoud, F., Nawaz, Z., Badii, R., Al-Sarraj, Y., Mbarek, H., Al-Muftah, W., Alvi, M., Rostami, M. R., Cruzado, J. C. M., Mezey, J. G., Shakaki, A. A., Malek, J. A., . . . Crystal, R. G. (2022). The QChip1 knowledgebase and microarray for precision medicine in Qatar. npj Genomic Medicine, 7(1), 3. doi: 10.1038/s41525-021-00270-0.