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The Department of Genetic Medicine at Weill Cornell leads a dynamic and innovative translational research program, advancing diverse fields such as Genetic Therapy and Personalized Medicine.
Gene Therapy for Immunoglobulin E, Complement-Mediated, and Eosinophilic Disorders.
| Publication Type | Review |
| Authors | Pagovich O, Crystal R |
| Journal | Hum Gene Ther |
| Volume | 34 |
| Issue | 19-20 |
| Pagination | 986-1002 |
| Date Published | 10/01/2023 |
| ISSN | 1557-7422 |
| Keywords | Immunoglobulin E, Eosinophils |
| Abstract | Immunoglobulin E, complement, and eosinophils play an important role in host defense, but dysfunction of each of these components can lead to a variety of human disorders. In this review, we summarize how investigators have adapted gene therapy and antisense technology to modulate immunoglobulin E, complement, and/or eosinophil levels to treat these disorders. |
| DOI | 10.1089/hum.2023.039 |
| PubMed ID | 37672523 |
| PubMed Central ID | PMC10616964 |