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Granulocyte collagenase: selective digestion of type I relative to type III collagen.
| Publication Type | Academic Article |
| Authors | Horwitz A, Hance A, Crystal R |
| Journal | Proc Natl Acad Sci U S A |
| Volume | 74 |
| Issue | 3 |
| Pagination | 897-901 |
| Date Published | 03/01/1977 |
| ISSN | 0027-8424 |
| Keywords | Fibroblasts, Macrophages, Microbial Collagenase, Neutrophils |
| Abstract | Collagenases produced by human polymorphonuclear leukocytes, human lung fibroblasts, and rabbit pulmonary alveolar macrophages were compared in their ability to digest soluble native type I and type III collagens. While the fibroblast and macrophage collagenases attacked the two substrates at approximately equal rates, the leukocyte collagenase attacked type I collagen preferentially (15:1) in comparison to type III collagen. This was true with human or rabbit collagen substrates. Thus, proteolysis of collagen, particularly in acute inflammation, may have a significant role in controlling the types of collagen present in connective tissue. |
| DOI | 10.1073/pnas.74.3.897 |
| PubMed ID | 191839 |
| PubMed Central ID | PMC430521 |