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Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity.
| Publication Type | Academic Article |
| Authors | Martinet Y, Bitterman P, Mornex J, Grotendorst G, Martin G, Crystal R |
| Journal | Nature |
| Volume | 319 |
| Issue | 6049 |
| Pagination | 158-60 |
| Date Published | 01/01/1986 |
| ISSN | 0028-0836 |
| Keywords | Monocytes, Platelet-Derived Growth Factor, Proto-Oncogenes |
| Abstract | Current ideas about the mechanism of wound healing and the pathogenesis of atherosclerosis, pulmonary fibrosis and hepatic fibrosis suggest a central role for the mononuclear phagocyte in attracting and/or stimulating the proliferation of mesenchymal cells. We demonstrate here that activated human blood monocytes, but not resting monocytes, release a mediator that attracts smooth muscle cells and cooperates with other mediators to stimulate fibroblast proliferation. This mediator is very similar to platelet-derived growth factor (PDGF): its chromatographic properties and chemical stability are similar to those of PDGF, it competes with 125I-PDGF for binding to fibroblasts and it immunoprecipitates with anti-PDGF antibodies. In parallel, stimulated monocytes, but not resting monocytes, express the c-sis proto-oncogene, a gene coding for one of the PDGF chains, consistent with the concept that expression of the c-sis proto-oncogene may be involved in the ability of mononuclear phagocytes to modulate the accumulation of mesenchymal cells. |
| DOI | 10.1038/319158a0 |
| PubMed ID | 3941744 |