Publication Type Review
Authors Boyer J, Kobinger G, Wilson J, Crystal R
Journal Hum Gene Ther
Volume 16
Issue 2
Pagination 157-68
Date Published 02/01/2005
ISSN 1043-0342
Keywords AIDS Vaccines, Adenoviridae, Bioterrorism, Communicable Disease Control, Genetic Therapy, HIV Infections
Abstract The robust host responses elicited against transgenes encoded by (E1-)(E3-) adenovirus (Ad) gene transfer vectors can be used to develop Ad-based vectors as platform technologies for vaccines against potential bioterror pathogens. This review focuses on pathogens of major concern as bioterror agents and why Ad vectors are ideal as anti-bioterror vaccine platforms, providing examples from our laboratories of using Ad vectors as vaccines against potential bioterror pathogens and how Ad vectors can be developed to enhance vaccine efficacy in the bioterror war.
DOI 10.1089/hum.2005.16.157
PubMed ID 15761256
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