Cardiac angiogenesis and gene therapy: a strategy for myocardial revascularization.

Publication Type Review
Authors Hamawy A, Lee L, Crystal R, Rosengart T
Journal Curr Opin Cardiol
Volume 14
Issue 6
Pagination 515-22
Date Published 11/01/1999
ISSN 0268-4705
Keywords Coronary Disease, Genetic Therapy, Myocardial Revascularization, Neovascularization, Pathologic
Abstract Angiogenesis, the de novo formation of new vasculature, is a critical response to ischemia that provides neovascularization of ischemic tissues. In therapeutic angiogenesis, an angiogen--a mediator that induces angiogenesis--is delivered to targeted tissues, augmenting the native angiogenic process and enhancing reperfusion of ischemic tissues. Gene transfer is a novel means of providing therapeutic angiogenesis: the cDNA coding for specific angiogens, rather than the proteins themselves, is administered to the tissues in which angiogenesis is desired. This review is focused on therapeutic angiogenesis based on gene transfer strategies for the provision of myocardial revascularization.
DOI 10.1097/00001573-199911000-00012
PubMed ID 10579070
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