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The Department of Genetic Medicine at Weill Cornell leads a dynamic and innovative translational research program, advancing diverse fields such as Genetic Therapy and Personalized Medicine.
Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs.
| Publication Type | Academic Article |
| Authors | Hicks M, De B, Rosenberg J, Davidson J, Moreno A, Janda K, Wee S, Koob G, Hackett N, Kaminsky S, Worgall S, Toth M, Mezey J, Crystal R |
| Journal | Mol Ther |
| Volume | 19 |
| Issue | 3 |
| Pagination | 612-9 |
| Date Published | 01/04/2011 |
| ISSN | 1525-0024 |
| Keywords | Cocaine, Substance-Related Disorders, Vaccines |
| Abstract | Based on the concept that anticocaine antibodies could prevent inhaled cocaine from reaching its target receptors in the brain, an effective anticocaine vaccine could help reverse cocaine addiction. Leveraging the knowledge that E1(-)E3(-) adenovirus (Ad) gene transfer vectors are potent immunogens, we have developed a novel vaccine platform for addictive drugs by covalently linking a cocaine analog to the capsid proteins of noninfectious, disrupted Ad vector. The Ad-based anticocaine vaccine evokes high-titer anticocaine antibodies in mice sufficient to completely reverse, on a persistent basis, the hyperlocomotor activity induced by intravenous administration of cocaine. |
| DOI | 10.1038/mt.2010.280 |
| PubMed ID | 21206484 |
| PubMed Central ID | PMC3048190 |