Corticosteroid therapy suppresses spontaneous interleukin 2 release and spontaneous proliferation of lung T lymphocytes of patients with active pulmonary sarcoidosis.
| Publication Type | Academic Article |
| Authors | Pinkston P, Saltini C, Müller-Quernheim J, Crystal R |
| Journal | J Immunol |
| Volume | 139 |
| Issue | 3 |
| Pagination | 755-60 |
| Date Published | 08/01/1987 |
| ISSN | 0022-1767 |
| Keywords | Adrenal Cortex Hormones, Interleukin-2, Lung, Lung Diseases, Sarcoidosis, T-Lymphocytes |
| Abstract | Active pulmonary sarcoidosis is characterized by the alveolar accumulation of activated helper T lymphocytes that are spontaneously releasing IL 2 and proliferating at an enhanced rate. In this regard, sarcoidosis represents a "model" human disorder to test in vivo the known in vitro action of corticosteroids on suppressing the activated IL 2 gene. Comparable groups of patients with active sarcoidosis were prospectively evaluated with no therapy or treated with corticosteroids. Over 3.2 +/- 0.4 mo, the untreated group had no significant change in spontaneous lung T cell release of IL 2 or spontaneous proliferation. In contrast, over the same period, the treated group had marked reduction of spontaneous lung T cell release of IL 2 and proliferation (p less than 0.01, all comparisons before therapy). Furthermore, Northern analysis of lung T cell RNA before therapy demonstrated IL 2 mRNA transcripts, whereas no IL 2 transcripts were observed during therapy. These observations are consistent with the concept that directly, or indirectly, corticosteroids are capable of suppressing the IL 2 gene in activated T lymphocytes in vivo. |
| PubMed ID | 3496388 |