Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis.

Publication Type Academic Article
Authors Borok Z, Buhl R, Grimes G, Bokser A, Hubbard R, Holroyd K, Roum J, Czerski D, Cantin A, Crystal R
Journal Lancet
Volume 338
Issue 8761
Pagination 215-6
Date Published 07/27/1991
ISSN 0140-6736
Keywords Bronchoalveolar Lavage Fluid, Glutathione, Oxygen, Pulmonary Fibrosis
Abstract Idiopathic pulmonary fibrosis (IPF) is characterised by alveolar inflammation, exaggerated release of oxidants, and subnormal concentrations of the antioxidant glutathione in respiratory epithelial lining fluid (ELF). Glutathione (600 mg twice daily for 3 days) was given by aerosol to 10 patients with IPF. Total ELF glutathione rose transiently, ELF oxidised glutathione concentrations increased, and there was a decrease in spontaneous superoxide anion release by alveolar macrophages. Thus, glutathione by aerosol could be a means of reversing the oxidant-antioxidant imbalance in IPF.
DOI 10.1016/0140-6736(91)90350-x
PubMed ID 1676780
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