Publication Type	Academic Article
Authors	Borok Z, Buhl R, Grimes G, Bokser A, Hubbard R, Holroyd K, Roum J, Czerski D, Cantin A, Crystal R
Journal	Lancet
Volume	338
Issue	8761
Pagination	215-6
Date Published	07/27/1991
ISSN	0140-6736
Keywords	Bronchoalveolar Lavage Fluid, Glutathione, Oxygen, Pulmonary Fibrosis
Abstract	Idiopathic pulmonary fibrosis (IPF) is characterised by alveolar inflammation, exaggerated release of oxidants, and subnormal concentrations of the antioxidant glutathione in respiratory epithelial lining fluid (ELF). Glutathione (600 mg twice daily for 3 days) was given by aerosol to 10 patients with IPF. Total ELF glutathione rose transiently, ELF oxidised glutathione concentrations increased, and there was a decrease in spontaneous superoxide anion release by alveolar macrophages. Thus, glutathione by aerosol could be a means of reversing the oxidant-antioxidant imbalance in IPF.
DOI	10.1016/0140-6736(91)90350-x
PubMed ID	1676780