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The Department of Genetic Medicine at Weill Cornell leads a dynamic and innovative translational research program, advancing diverse fields such as Genetic Therapy and Personalized Medicine.
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Our translational research program aims to leverage our expertise in genetic therapies and personalized medicine to develop clinical solutions that target the molecular causes of human diseases.
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Crystal Clinic

Gene Therapy for Immunoglobulin E, Complement-Mediated, and Eosinophilic Disorders.

Publication Type	Review
Authors	Pagovich O, Crystal R
Journal	Hum Gene Ther
Volume	34
Issue	19-20
Pagination	986-1002
Date Published	10/01/2023
ISSN	1557-7422
Keywords	Immunoglobulin E, Eosinophils
Abstract	Immunoglobulin E, complement, and eosinophils play an important role in host defense, but dysfunction of each of these components can lead to a variety of human disorders. In this review, we summarize how investigators have adapted gene therapy and antisense technology to modulate immunoglobulin E, complement, and/or eosinophil levels to treat these disorders.
DOI	10.1089/hum.2023.039
PubMed ID	37672523
PubMed Central ID	PMC10616964