Genetic control of wayward pluripotent stem cells and their progeny after transplantation.

Publication Type Academic Article
Authors Kiuru M, Boyer J, O'Connor T, Crystal R
Journal Cell Stem Cell
Volume 4
Issue 4
Pagination 289-300
Date Published 04/03/2009
ISSN 1875-9777
Keywords Cell Differentiation, Neoplastic Stem Cells, Pluripotent Stem Cells, Stem Cell Transplantation, Transplantation Conditioning
Abstract The proliferative capacity of pluripotent stem cells and their progeny brings a unique aspect to therapeutics, in that once a transplant is initiated the therapist no longer has control of the therapy. In the context of the recent FDA approval of a human ESC trial and report of a neuronal-stem-cell-derived tumor in a human trial, strategies need to be developed to control wayward pluripotent stem cells. Here, we focus on one approach: direct genetic modification of the cells prior to transplantation with genes that can prevent the adverse events and/or eliminate the transplanted cells and their progeny.
DOI 10.1016/j.stem.2009.03.010
PubMed ID 19341619
PubMed Central ID PMC3254150
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