Intracellular degradation of newly synthesized collagen.

Publication Type	Review
Authors	Rennard S, Stier L, Crystal R
Journal	J Invest Dermatol
Volume	79 Suppl 1
Pagination	77s-82s
Date Published	07/01/1982
ISSN	0022-202X
Keywords	Collagen
Abstract	The intracellular degradation of newly synthesized collagen is a cellular pathway that accounts for the destruction of 10-60% of collagen synthesized by a variety of cell types prior to secretion. This pathway can serve in a regulatory role to limit the secretion of defective molecules, and, in response to some extracellular mediators, regulates the amount and type of collagens secreted. In addition, this pathway may contribute to the pathogenesis of a variety of conditions affecting the extracellular matrix including fibrosis, diabetes mellitus, and scurvy.
DOI	10.1111/1523-1747.ep12545844
PubMed ID	6806401