The Department of Genetic Medicine at Weill Cornell leads a dynamic and innovative translational research program, advancing diverse fields such as Genetic Therapy and Personalized Medicine.
Our translational research program aims to leverage our expertise in genetic therapies and personalized medicine to develop clinical solutions that target the molecular causes of human diseases.
The Department of Genetic Medicine advances treatments and diagnostics through diverse clinical trials, including drug testing and research to better understand diseases.
The Department of Genetic Medicine at Weill Cornell leads a dynamic and innovative translational research program, advancing diverse fields such as Genetic Therapy and Personalized Medicine.
Our translational research program aims to leverage our expertise in genetic therapies and personalized medicine to develop clinical solutions that target the molecular causes of human diseases.
The Department of Genetic Medicine advances treatments and diagnostics through diverse clinical trials, including drug testing and research to better understand diseases.
Unilateral pneumonectomy in the adult rabbit causes the mass of the remaining lung to double within one month. The content and synthesis of lung collagen were compared in 113 rabbits with pneumonectomy, thoracotomy without pneumonectomy, or pneumonectomy with subsequent wax plombage. By the twenty eighth day after left pneumonectomy, total lung collagen and cell number were nearly 100 per cent greater than matched control values, but the density of both collagen and cell number remained constant and unchanged from control. This collagen accumlation was preceded by an increase in the rate of collagen synthesis per cell and in the per cent of lung total protein synthesis represented by collagen synthesis. In normal neonatal lung growth, total lung mass, collagen, and cell number increase. During this same period there is also an increase in the per cent of collagen synthesis represented by lung total protein synthesis; however, in contrast to postpneumonectomy adult lung growth, the density of collagen increases. Obliteration of the empty hemithorax with wax after pneumonectomy resulted in suppression of the increases in right lung cell number, collagen synthesis, and collagen accumlation seen with pneumonectomy alone. This could have generalized implications relating to the control of lung gene expression in that lung cell replication and/or lung cell differentiation may, in part, be controlled by the available space into which the lung may grow.