Macaque model for severe acute respiratory syndrome.

Publication Type	Academic Article
Authors	Rowe T, Gao G, Hogan R, Crystal R, Voss T, Grant R, Bell P, Kobinger G, Wivel N, Wilson J
Journal	J Virol
Volume	78
Issue	20
Pagination	11401-4
Date Published	10/01/2004
ISSN	0022-538X
Keywords	Disease Models, Animal, Severe acute respiratory syndrome-related coronavirus, Severe Acute Respiratory Syndrome
Abstract	Rhesus and cynomolgus macaques were challenged with 10(7) PFU of a clinical isolate of the severe acute respiratory syndrome (SARS) coronavirus. Some of the animals developed a mild self-limited respiratory infection very different from that observed in humans with SARS. The macaque model as it currently exists will have limited utility in the study of SARS and the evaluation of therapies.
DOI	10.1128/JVI.78.20.11401-11404.2004
PubMed ID	15452262
PubMed Central ID	PMC521815