Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine.
| Publication Type | Academic Article |
| Authors | Crystal R, Hirschowitz E, Lieberman M, Daly J, Kazam E, Henschke C, Yankelevitz D, Kemeny N, Silverstein R, Ohwada A, Russi T, Mastrangeli A, Sanders A, Cooke J, Harvey B |
| Journal | Hum Gene Ther |
| Volume | 8 |
| Issue | 8 |
| Pagination | 985-1001 |
| Date Published | 05/20/1997 |
| ISSN | 1043-0342 |
| Keywords | Adenoviridae, Antimetabolites, Flucytosine, Genetic Therapy, Genetic Vectors, Liver Neoplasms, Prodrugs |
| DOI | 10.1089/hum.1997.8.8-985 |
| PubMed ID | 9195221 |