Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine.

Publication Type	Academic Article
Authors	Crystal R, Hirschowitz E, Lieberman M, Daly J, Kazam E, Henschke C, Yankelevitz D, Kemeny N, Silverstein R, Ohwada A, Russi T, Mastrangeli A, Sanders A, Cooke J, Harvey B
Journal	Hum Gene Ther
Volume	8
Issue	8
Pagination	985-1001
Date Published	05/20/1997
ISSN	1043-0342
Keywords	Adenoviridae, Antimetabolites, Flucytosine, Genetic Therapy, Genetic Vectors, Liver Neoplasms, Prodrugs
DOI	10.1089/hum.1997.8.8-985
PubMed ID	9195221