Prevalence of diverticulosis in recurrent Clostridium difficile infection.

Publication Type Academic Article
Authors Lipp M, Pagovich O, Rabin D, Min A, Bernstein B
Journal World J Gastroenterol
Volume 16
Issue 3
Pagination 345-7
Date Published 01/21/2010
ISSN 2219-2840
Keywords Clostridioides difficile, Diverticulosis, Colonic, Enterocolitis, Pseudomembranous
Abstract AIM: To re-evaluate the theory that colonic diverticulosis is associated with relapse of Clostridium difficile associated disease (CDAD) in light of data suggesting increasing rates of CDAD infection and relapse. METHODS: Charts were reviewed for patients with recurrent CDAD who had also had a prior colonoscopy or flexible sigmoidoscopy. An age and gender matched control group was used to compare the prevalence of diverticulosis. RESULTS: Twenty-two patients met the study criteria, and the prevalence of diverticulosis in patients with CDAD relapse was 23% compared to 32% in age and sex matched controls (P = 0.44). A significant proportion of patients with CDAD relapse had co-morbidities associated with immune suppression. CONCLUSION: Diverticulosis does not appear to be associated with CDAD relapse.
DOI 10.3748/wjg.v16.i3.345
PubMed ID 20082480
PubMed Central ID PMC2807955
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