Publication Type	Academic Article
Authors	Ballon D, Jakubowski A, Tulipano P, Graham M, Schneider E, Aghazadeh B, Chen Q, Koutcher J
Journal	Magn Reson Med
Volume	39
Issue	5
Pagination	789-800
Date Published	05/01/1998
ISSN	0740-3194
Keywords	Algorithms, Bone Marrow, Hematopoiesis, Magnetic Resonance Imaging
Abstract	Spatial maps of the percentage cellularity in pelvic bone marrow were calculated at a resolution of 15.6 mm3 from six volunteers and 10 patients treated for documented hematologic disease using a three-point Dixon MRI pulse sequence. The percentage cellularity calculation was aided by analyzing a two-dimensional feature space consisting of the apparent water fraction (Wa), and the T2 relaxation time of water (T2w). An extracellular water fraction was assigned to each voxel on the basis of a two-component T2w algorithm. In six cases, the method was compared to results obtained from core biopsies or aspirates of the posterior iliac crest. The results indicate that segmentation schemes that combine high-quality phase-contrast imaging with nuclear relaxation time measurements can potentially identify the true fractional marrow volume occupied by hematopoietic elements in a variety of clinical situations.
DOI	10.1002/mrm.1910390517
PubMed ID	9581611