Publication Type	Academic Article
Journal	Chest
Volume	106
Issue	4
Pagination	1223-32
Date Published	10/01/1994
ISSN	0012-3692
Keywords	Registries, alpha 1-Antitrypsin Deficiency
Abstract	The Registry of Patients with Severe Deficiency of Alpha 1-Antitrypsin (A1AT) is a multicenter natural history study, with 37 participating clinical centers in the United States (36 centers) and Canada (1 center). The study has enrolled 1,129 individuals aged > or = 18 years with severe deficiency of A1AT (serum level < or = 11 microM), and will follow them longitudinally for up to 7 years, characterizing the clinical course of the disease, regardless of whether they are receiving augmentation therapy. Primary outcomes of interest are the yearly decline in FEV1 and mortality. This article describes the design and structure of the Registry.
PubMed ID	7924498