The Department of Genetic Medicine at Weill Cornell leads a dynamic and innovative translational research program, advancing diverse fields such as Genetic Therapy and Personalized Medicine.
Our translational research program aims to leverage our expertise in genetic therapies and personalized medicine to develop clinical solutions that target the molecular causes of human diseases.
The Department of Genetic Medicine advances treatments and diagnostics through diverse clinical trials, including drug testing and research to better understand diseases.
The Department of Genetic Medicine at Weill Cornell leads a dynamic and innovative translational research program, advancing diverse fields such as Genetic Therapy and Personalized Medicine.
Our translational research program aims to leverage our expertise in genetic therapies and personalized medicine to develop clinical solutions that target the molecular causes of human diseases.
The Department of Genetic Medicine advances treatments and diagnostics through diverse clinical trials, including drug testing and research to better understand diseases.
Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1.
Publication Type
Academic Article
Authors
Hogan R, Gao G, Rowe T, Bell P, Flieder D, Paragas J, Kobinger G, Wivel N, Crystal R, Boyer J, Feldmann H, Voss T, Wilson J
Journal
J Virol
Volume
78
Issue
20
Pagination
11416-21
Date Published
10/01/2004
ISSN
0022-538X
Keywords
DNA-Binding Proteins, Severe acute respiratory syndrome-related coronavirus, Severe Acute Respiratory Syndrome, Trans-Activators
Abstract
Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed by rapid clearance of virus from the lungs and the development of self-limited bronchiolitis. Animals resistant to the effects of interferons by virtue of a deficiency in Stat1 demonstrated a markedly different course following intranasal inhalation of SARS CoV, one characterized by replication of virus in lungs and progressively worsening pulmonary disease with inflammation of small airways and alveoli and systemic spread of the virus to livers and spleens.