Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1.

Publication Type Academic Article
Authors Hogan R, Gao G, Rowe T, Bell P, Flieder D, Paragas J, Kobinger G, Wivel N, Crystal R, Boyer J, Feldmann H, Voss T, Wilson J
Journal J Virol
Volume 78
Issue 20
Pagination 11416-21
Date Published 10/01/2004
ISSN 0022-538X
Keywords DNA-Binding Proteins, Severe acute respiratory syndrome-related coronavirus, Severe Acute Respiratory Syndrome, Trans-Activators
Abstract Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed by rapid clearance of virus from the lungs and the development of self-limited bronchiolitis. Animals resistant to the effects of interferons by virtue of a deficiency in Stat1 demonstrated a markedly different course following intranasal inhalation of SARS CoV, one characterized by replication of virus in lungs and progressively worsening pulmonary disease with inflammation of small airways and alveoli and systemic spread of the virus to livers and spleens.
DOI 10.1128/JVI.78.20.11416-11421.2004
PubMed ID 15452265
PubMed Central ID PMC521834
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