Results of retroviral and adenoviral approaches to cancer gene therapy.

Publication Type Review
Authors Yin L, Fu S, Nanakorn T, Garcia-Sanchez F, Chung I, Cote R, Pizzorno G, Hanania E, Heimfeld S, Crystal R, Deisseroth A
Journal Stem Cells
Volume 16 Suppl 1
Pagination 247-50
Date Published 01/01/1998
ISSN 1066-5099
Keywords ATP Binding Cassette Transporter, Subfamily B, Member 1, Adenoviridae, Breast Neoplasms, Gene Transfer Techniques, Genes, MDR, Genetic Therapy, Genetic Vectors, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Neoplasms, Ovarian Neoplasms, Retroviridae
Abstract Genetic modification for cancer treatment has involved the introduction of chemotherapy protection and sensitization genes into normal and tumor cells, respectively, for the purpose of improving the outcome of conventional approaches to the treatment of solid tumor neoplasms. This paper will review the use of multidrug resistance-1 retroviral vectors and cytosine deaminase adenoviral prodrug activation vectors for this purpose.
DOI 10.1002/stem.5530160830
PubMed ID 11012168
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