Results of retroviral and adenoviral approaches to cancer gene therapy.
| Publication Type | Review |
| Authors | Yin L, Fu S, Nanakorn T, Garcia-Sanchez F, Chung I, Cote R, Pizzorno G, Hanania E, Heimfeld S, Crystal R, Deisseroth A |
| Journal | Stem Cells |
| Volume | 16 Suppl 1 |
| Pagination | 247-50 |
| Date Published | 01/01/1998 |
| ISSN | 1066-5099 |
| Keywords | ATP Binding Cassette Transporter, Subfamily B, Member 1, Adenoviridae, Breast Neoplasms, Gene Transfer Techniques, Genes, MDR, Genetic Therapy, Genetic Vectors, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Neoplasms, Ovarian Neoplasms, Retroviridae |
| Abstract | Genetic modification for cancer treatment has involved the introduction of chemotherapy protection and sensitization genes into normal and tumor cells, respectively, for the purpose of improving the outcome of conventional approaches to the treatment of solid tumor neoplasms. This paper will review the use of multidrug resistance-1 retroviral vectors and cytosine deaminase adenoviral prodrug activation vectors for this purpose. |
| DOI | 10.1002/stem.5530160830 |
| PubMed ID | 11012168 |