Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population.
| Publication Type | Academic Article |
| Authors | Upadhyay R, Robay A, Fakhro K, Abi Khalil C, Zirie M, Jayyousi A, El-Shafei M, Kiss S, D'Amico D, Salit J, Staudt M, O'Beirne S, Chen X, Tuana B, Crystal R, Ding H |
| Journal | J Transl Med |
| Volume | 13 |
| Pagination | 61 |
| Date Published | 02/15/2015 |
| ISSN | 1479-5876 |
| Keywords | Diabetes Mellitus, Type 2, Diabetic Retinopathy, Genetic Predisposition to Disease, Membrane Proteins, Polymorphism, Single Nucleotide |
| Abstract | BACKGROUND: Overexpression of SLMAP gene has been associated with diabetes and endothelial dysfunction of macro- and micro-blood vessels. In this study our primary objective is to explore the role of SLMAP gene polymorphisms in the susceptibility of type 2 diabetes (T2DM) with or without diabetic retinopathy (DR) in the Qatari population. METHODS: A total of 342 Qatari subjects (non-diabetic controls and T2DM patients with or without DR) were genotyped for SLMAP gene polymorphisms (rs17058639 C > T; rs1043045 C > T and rs1057719 A > G) using Taqman SNP genotyping assay. RESULTS: SLMAP rs17058639 C > T polymorphism was associated with the presence of DR among Qataris with T2DM. One-way ANOVA and multiple logistic regression analysis showed SLMAP SNP rs17058639 C > T as an independent risk factor for DR development. SLMAP rs17058639 C > T polymorphism also had a predictive role for the severity of DR. Haplotype Crs17058639Trs1043045Ars1057719 was associated with the increased risk for DR among Qataris with T2DM. CONCLUSIONS: The data suggests the potential role of SLMAP SNPs as a risk factor for the susceptibility of DR among T2DM patients in the Qatari population. |
| DOI | 10.1186/s12967-015-0411-6 |
| PubMed ID | 25880194 |
| PubMed Central ID | PMC4335364 |