Publication Type Review
Authors Crystal R
Journal Science
Volume 270
Issue 5235
Pagination 404-10
Date Published 10/20/1995
ISSN 0036-8075
Keywords Gene Transfer Techniques, Genetic Therapy
Abstract Enough information has been gained from clinical trials to allow the conclusion that human gene transfer is feasible, can evoke biologic responses that are relevant to human disease, and can provide important insights into human biology. Adverse events have been uncommon and have been related to the gene delivery strategies, not to the genetic material being transferred. Human gene transfer still faces significant hurdles before it becomes an established therapeutic strategy. However, its accomplishments to date are impressive, and the logic of the potential usefulness of this clinical paradigm continues to be compelling.
DOI 10.1126/science.270.5235.404
PubMed ID 7569994
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