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In vivo measurements of bone marrow cellularity using volume-localized proton NMR spectroscopy.
| Publication Type | Academic Article |
| Authors | Ballon D, Jakubowski A, Gabrilove J, Graham M, Zakowski M, Sheridan C, Koutcher J |
| Journal | Magn Reson Med |
| Volume | 19 |
| Issue | 1 |
| Pagination | 85-95 |
| Date Published | 05/01/1991 |
| ISSN | 0740-3194 |
| Keywords | Bone Marrow, Magnetic Resonance Imaging |
| Abstract | Volume-localized proton NMR spectroscopy was used to estimate bone marrow cellularity in the posterior iliac crests of patients undergoing treatment with hematopoietic growth factors for a variety of hematologic and neoplastic disorders. Twelve patients were accrued, six of whom were studied more than once, yielding a total of 25 measurements. These data were compared to cellularity assessments derived from conventional bone marrow core biopsies obtained within a 24-h period before or after the NMR exam. The results obtained by the two methods are well correlated (R = 0.94, P less than 0.001), suggesting that this noninvasive technique may preclude the need for biopsies in some cases. |
| DOI | 10.1002/mrm.1910190108 |
| PubMed ID | 2046540 |