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In vivo multiple-mouse imaging at 1.5 T.
| Publication Type | Academic Article |
| Authors | Xu S, Gade T, Matei C, Zakian K, Alfieri A, Hu X, Holland E, Soghomonian S, Tjuvajev J, Ballon D, Koutcher J |
| Journal | Magn Reson Med |
| Volume | 49 |
| Issue | 3 |
| Pagination | 551-7 |
| Date Published | 03/01/2003 |
| ISSN | 0740-3194 |
| Keywords | Brain Neoplasms, Lung Neoplasms, Magnetic Resonance Imaging, Models, Animal |
| Abstract | A multiple-mouse solenoidal MR coil was developed for in vivo imaging of up to 13 mice simultaneously to screen for tumors on a 1.5 T clinical scanner. For the coil to be effective as a screening tool, it should permit acquisition of MRIs in which orthotopic tumors with diameters >2 mm are detectable in a reasonable period of time (<1 hr magnet time) and their sizes accurately measured. Using a spin echo sequence, we demonstrated that this coil provides sufficient sensitivity for moderately high resolution images (156-176 microm in plane-resolution, 1.5 mm slice thickness). This spatial resolution permitted detection of primary brain tumors in transgenic/knockout mice and orthotopic xenografts. Brain tumor size as measured by MRI was correlated with size measured by histopathology (P < 0.001). Metastatic tumors in the mouse lung were also successfully imaged in a screening setting. The multiple mouse coil is simple in construction and may be implemented without any significant modification to the hardware or software on a clinical scanner. |
| DOI | 10.1002/mrm.10397 |
| PubMed ID | 12594759 |